Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Flt4  FMS-like tyrosine kinase 4   (Synonyms: Flt-4, VEGFR3, VEGFR-3)
Results	Reference
1	J:233304 Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS, Mechanotransduction activates canonical Wnt/beta-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 15;30(12):1454-69
1	J:159824 Chen L, Mupo A, Huynh T, Cioffi S, Woods M, Jin C, McKeehan W, Thompson-Snipes L, Baldini A, Illingworth E, Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol. 2010 May 3;189(3):417-24
1	J:329888 Cioffi S, Flore G, Martucciello S, Bilio M, Turturo MG, Illingworth E, VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome. Life Sci Alliance. 2022 Dec;5(12):e202101308
1	J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
1*	J:136041 Gage PJ, Qian M, Wu D, Rosenberg KI, The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol. 2008 May 1;317(1):310-24
1*	J:137168 Gordon EJ, Gale NW, Harvey NL, Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn. 2008 Jul;237(7):1901-9
1	J:173649 Kanady JD, Dellinger MT, Munger SJ, Witte MH, Simon AM, Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol. 2011 Jun 15;354(2):253-66
1*	J:225741 Kanady JD, Munger SJ, Witte MH, Simon AM, Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling. Dev Biol. 2015 Sep 1;405(1):33-46
1	J:170175 Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL, Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40
1	J:317975 Lu P, Wang Y, Liu Y, Wang Y, Wu B, Zheng D, Harvey RP, Zhou B, Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 Sep;23(9):967-977
1	J:335167 Lu P, Wu B, Wang Y, Russell M, Liu Y, Bernard DJ, Zheng D, Zhou B, Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis. Dev Cell. 2023 Mar 29;
1	J:305417 Martucciello S, Turturo MG, Bilio M, Cioffi S, Chen L, Baldini A, Illingworth E, A dual role for Tbx1 in cardiac lymphangiogenesis through genetic interaction with Vegfr3. FASEB J. 2020 Nov;34(11):15062-15079
1	J:262023 Morooka N, Futaki S, Sato-Nishiuchi R, Nishino M, Totani Y, Shimono C, Nakano I, Nakajima H, Mochizuki N, Sekiguchi K, Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
1	J:213874 Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J, Notch signaling functions in lymphatic valve formation. Development. 2014 Jun;141(12):2446-51
1	J:275825 Norman TA Jr, Gower AC, Chen F, Fine A, Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019;14(5):e0216795
1	J:181330 Sabine A, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hagerling R, Pollmann C, Bebber D, Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Makinen T, Kiefer F, Kwak BR, Petrova TV, Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation. Dev Cell. 2012 Feb 14;22(2):430-45